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Your mouth & your mind

Gum bacteria found in Alzheimer's brains

The oral–brain connection is one of the most exciting frontiers in modern medicine — and protecting your gums today may be protecting your future self.

Your mouth & your mind
What the research shows

The evidence

  1. 1

    In a landmark 2019 Science Advances study, P. gingivalis and its toxic gingipain enzymes were identified in the brains of Alzheimer's patients, with levels tracking the disease's hallmark tau pathology.

  2. 2

    In mice, oral infection led the bacteria to colonize the brain and increase amyloid-beta.

  3. 3

    A 2022 Periodontology 2000 review concluded the evidence increasingly points to a plausible causative role — making prevention a hopeful strategy.

Peer-reviewed sources

References

Porphyromonas gingivalis in Alzheimer's disease brains

Dominy SS, et al. · Science Advances · 2019

Periodontal microorganisms and Alzheimer disease — A causative relationship?

Jungbauer G, et al. · Periodontology 2000 · 2022

P. gingivalis vesicles induce trigeminal nerve-mediated cognitive impairment

Ma X, et al. · J Advanced Research · 2023

Research retrieved via PubMed (U.S. National Library of Medicine). Associations in observational research do not by themselves prove causation; we share this to inspire prevention, not as medical advice or diagnosis.

The good news

What this means for you

Protecting your gums today is an investment in your future, clear-headed self — and it starts with one gentle visit.

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